Combine ground chicken, breadcrumbs, egg, garlic powder, onion powder, salt, and pepper in a large bowl; mix gently until just combined.

Divide the mixture into four equal portions and form into 1/2-inch thick patties, making a slight indentation in the center of each.

Heat a non-stick skillet or grill pan over medium-high heat, adding a tablespoon of oil if needed.

Cook the chicken patties for 5-7 minutes per side, or until golden brown and cooked through.

Lightly toast the burger buns during the last few minutes of cooking the patties.

Assemble the burgers by placing a cooked patty on the bottom bun, topping with lettuce, tomato, onion, cheese (if using), and your favorite sauce, then covering with the top bun.